In this podcast, Dr. Nimira Alimohamed and Dr. Aly-Khan Lalani review the recent data from trials in advanced bladder cancer including the 5-year survival update of the KEYNOTE-045 trial presented at ASCO in June 2021. The hosts will discuss the impact of immunotherapy and other novel therapeutic strategies on the management of patients with advanced bladder cancer in Canada.
Podcast Host Disclosures:
Dr. Alimohamed has had a consulting or advisory role with Astellas Pharma, AstraZeneca, Janssen, Merck, Pfizer, and Sanofi Canada.
Dr. Lalani has received honoraria from Astellas Pharma, Bayer, Bristol-Myers Squibb, Merck, Novartis, Pfizer, Roche/Genentech, and TerSera; has had a consulting or advisory role with Abbvie, Astellas Pharma, Bayer, Bristol-Myers Squibb, Eisai, Ipsen, Janssen, Merck, Pfizer, Roche/Genentech, and TerSera; and has received research funding from Bristol-Myers Squibb (Inst), Ipsen, Novartis, and Roche.
This podcast was accredited by the Canadian Urological Association in accordance with the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.
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Bellmunt J, et al. Pembrolizumab (pembro) versus investigator’s choice of paclitaxel, docetaxel, or vinflunine in recurrent, advanced urothelial cancer (UC): 5-year follow-up from the phase 3 KEYNOTE-045 trial. J Clin Oncol. 2021;39(suppl 15): abstr 4532. https://bit.ly/3axehzb
Loriot Y, et al. Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma. N Engl J Med. 2019;381(4):338-348. https://www.nejm.org/doi/full/10.1056/NEJMoa1817323
O’Donnell PH, et al. First-line pembrolizumab (pembro) in cisplatin-ineligible patients with advanced urothelial cancer (UC): Response and survival results up to five years from the KEYNOTE-052 phase 2 study. J Clin Oncol. 2021;39(suppl 15): abstr 4508. https://bit.ly/3gyklv5
Powles T, et al. Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma. N Engl J Med. 2020;383(13):1218-1230. https://www.nejm.org/doi/full/10.1056/NEJMoa2002788
Powles T, et al. Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma. N Engl J Med. 2021;384(12):1125-1135. https://www.nejm.org/doi/full/10.1056/NEJMoa2035807